'I have during the last four weeks obtained some results which I believe will interest you and Miss Buchanan.

I found that by placing the back of my hand and wrist in ice water [inserted: '(7° C)'] without letting it touch the palm I could lower the temperature of the palm appreciably; a thermometer secured to the palm with surgeon's [plaster?] showed a fall of about 3°C in 15 minutes. From this I concluded that complete immersion of the hand and half the forearm in ice water (6° or 7°C) for a similar time would lower the temperature of the entire hand still more than that. By using Piper's technique, slightly modified, I recorded the action current of the first dorsal interosseous muscle [crossed through: 'first with the'] in voluntary contraction, first with the hand at normal temperature, second after 15 minutes immersion in water at about 7°C, and finally after 10 or 15 min immersion in water at 45° to 47°C.

This simple chilling produces in every case a striking slowing of rhythm with greatly increased amplitude of individual excursions. I enclose prints from my films taken from a student who is working on it with me. I have obtained this result regularly in three or four experiments in which I have used this procedure. I intend to repeat it two or three times more to make sure, and then publish the results with a discussion of the recent work of Lucas and Adrian. It seems to me that with a proper consideration of the "relative refractory period" there is a ready answer to Piper's objection to some of Miss Buchanan's contentions, viz. that the observed muscle rhythm is not an index of the rhythm of nervous discharge.

I think I can show that although, as Piper states, a muscel stimulated by 200-300 induction shocks a second will respond with action currents at the same rate, still it is possible that nerve impulses at a rate of 500 - 600 per second may only evoke 50 propagated disturbances per second in the muscle.'

'I have during the last four weeks obtained some results which I believe will interest you and Miss Buchanan.

I found that by placing the back of my hand and wrist in ice water [inserted: '(7° C)'] without letting it touch the palm I could lower the temperature of the palm appreciably; a thermometer secured to the palm with surgeon's [plaster?] showed a fall of about 3°C in 15 minutes. From this I concluded that complete immersion of the hand and half the forearm in ice water (6° or 7°C) for a similar time would lower the temperature of the entire hand still more than that. By using Piper's technique, slightly modified, I recorded the action current of the first dorsal interosseous muscle [crossed through: 'first with the'] in voluntary contraction, first with the hand at normal temperature, second after 15 minutes immersion in water at about 7°C, and finally after 10 or 15 min immersion in water at 45° to 47°C.

This simple chilling produces in every case a striking slowing of rhythm with greatly increased amplitude of individual excursions. I enclose prints from my films taken from a student who is working on it with me. I have obtained this result regularly in three or four experiments in which I have used this procedure. I intend to repeat it two or three times more to make sure, and then publish the results with a discussion of the recent work of Lucas and Adrian. It seems to me that with a proper consideration of the "relative refractory period" there is a ready answer to Piper's objection to some of Miss Buchanan's contentions, viz. that the observed muscle rhythm is not an index of the rhythm of nervous discharge.

I think I can show that although, as Piper states, a muscel stimulated by 200-300 induction shocks a second will respond with action currents at the same rate, still it is possible that nerve impulses at a rate of 500 - 600 per second may only evoke 50 propagated disturbances per second in the muscle.'

'I have during the last four weeks obtained some results which I believe will interest you and Miss Buchanan.

I found that by placing the back of my hand and wrist in ice water [inserted: '(7° C)'] without letting it touch the palm I could lower the temperature of the palm appreciably; a thermometer secured to the palm with surgeon's [plaster?] showed a fall of about 3°C in 15 minutes. From this I concluded that complete immersion of the hand and half the forearm in ice water (6° or 7°C) for a similar time would lower the temperature of the entire hand still more than that. By using Piper's technique, slightly modified, I recorded the action current of the first dorsal interosseous muscle [crossed through: 'first with the'] in voluntary contraction, first with the hand at normal temperature, second after 15 minutes immersion in water at about 7°C, and finally after 10 or 15 min immersion in water at 45° to 47°C.

This simple chilling produces in every case a striking slowing of rhythm with greatly increased amplitude of individual excursions. I enclose prints from my films taken from a student who is working on it with me. I have obtained this result regularly in three or four experiments in which I have used this procedure. I intend to repeat it two or three times more to make sure, and then publish the results with a discussion of the recent work of Lucas and Adrian. It seems to me that with a proper consideration of the "relative refractory period" there is a ready answer to Piper's objection to some of Miss Buchanan's contentions, viz. that the observed muscle rhythm is not an index of the rhythm of nervous discharge.

I think I can show that although, as Piper states, a muscel stimulated by 200-300 induction shocks a second will respond with action currents at the same rate, still it is possible that nerve impulses at a rate of 500 - 600 per second may only evoke 50 propagated disturbances per second in the muscle.'

'I have during the last four weeks obtained some results which I believe will interest you and Miss Buchanan.

I found that by placing the back of my hand and wrist in ice water [inserted: '(7° C)'] without letting it touch the palm I could lower the temperature of the palm appreciably; a thermometer secured to the palm with surgeon's [plaster?] showed a fall of about 3°C in 15 minutes. From this I concluded that complete immersion of the hand and half the forearm in ice water (6° or 7°C) for a similar time would lower the temperature of the entire hand still more than that. By using Piper's technique, slightly modified, I recorded the action current of the first dorsal interosseous muscle [crossed through: 'first with the'] in voluntary contraction, first with the hand at normal temperature, second after 15 minutes immersion in water at about 7°C, and finally after 10 or 15 min immersion in water at 45° to 47°C.

This simple chilling produces in every case a striking slowing of rhythm with greatly increased amplitude of individual excursions. I enclose prints from my films taken from a student who is working on it with me. I have obtained this result regularly in three or four experiments in which I have used this procedure. I intend to repeat it two or three times more to make sure, and then publish the results with a discussion of the recent work of Lucas and Adrian. It seems to me that with a proper consideration of the "relative refractory period" there is a ready answer to Piper's objection to some of Miss Buchanan's contentions, viz. that the observed muscle rhythm is not an index of the rhythm of nervous discharge.

I think I can show that although, as Piper states, a muscel stimulated by 200-300 induction shocks a second will respond with action currents at the same rate, still it is possible that nerve impulses at a rate of 500 - 600 per second may only evoke 50 propagated disturbances per second in the muscle.'